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PROFILE

Dr. Arunaksharan N.

DEPARTMENT OF ZOOLOGY

  • DESIGNATION
    Assistant Professor
  • Mobile
    9847793528
  • E-MAIL
    dr.arunaksharan@gmail.com
  • EXPERIENCE
    6 years
  • QUALIFICATION
    MSc, PhD
  • AREA OF INTEREST
    Cancer Biology, Pharmacology, Toxicology, Food Science
  • ADDRESS
    Sreepadmam, Makkat, Puthoormadam, Pantheerankave PO Kozhikode- 673019
FACULTY DETAILS

Dr. Arunaksharan Narayanankutty   

  Lab Website (DCMB)

                                     

                                                                   

Research Area and Interest

  • Pharmacology, Toxicology, Nutrition, and Drug Discovery
  • Management of Cancers, Non-Alcoholic Fatty Liver Disease, Diabetes and Obesity
  • Functional foods, Nutraceuticals, Bioactive compounds from plants
  • Phytochemical analysis and active compoud purification
  • Essential oils, Pest and Vector Control

Research Metrics

Publications

Impact factor

Books

Citations

H-Index

i-10 Index

88

295.5

46

2683

26

54

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Research Profiles:

  1. ORCID                       : 0000-0002-6232-1665
  2. Researcher ID             : D-7288-2015
  3. Scopus ID                   : 56912454400
  4. Kudos                         : 143802
  5. Publons                       : a/995244/
  6. Google Scholar           : Arunaksharan Narayanankutty
  7. Researchgate               : Arunaksharan Narayanankutty

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Work Experience 

Sl. No.

Position

Institute

From

To

1

Assistant Professor

St. Joseph’s College, Devagiri, Calicut

20-12-2021

Present

2

Guest Lecturer

St. Joseph’s College, Devagiri, Calicut

16-06-2020

 19-12-2021

3

Guest Lecturer

Malabar Christian College, Calicut

06-06-2019

31-03-2020

4

Guest Lecturer

St. Joseph’s College, Devagiri, Calicut

08-10-2018

31-03-2019

5

Senior Research Fellow (SRF)

Amala Cancer Research Centre, Thrissur

01-10-2015

30-09-2018

6

Junior Research Fellow (JRF)

Amala Cancer Research Centre, Thrissur

02-09-2013

30-09-2015

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Educational Qualifications: 

Sl. No.

Course

Institute

University/ Board

Year and Month

1

Ph. D. in Biochemistry (Zoology)

Amala Cancer Research Centre

University of Calicut

2019, November

2.

M.Sc. Zoology

St. Joseph’s College, Devagiri

University of Calicut

2012, October

3.

B.Ed. Natural Science

Govt. College of Teacher Education, Mananchira

University of Calicut

2013, October

4.

B.Sc. Zoology

St. Joseph’s College, Devagiri

University of Calicut

2010, May

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JOURNAL EDITORSHIP

  1. Associate Editor, New Zealand Journal of Botany. (https://rsnz.onlinelibrary.wiley.com/journal/11758643). Impact Factor: 1.4 (SCI/PubMed/Medline/Scopus Indexed)
  2. Guest Editor, Natural Product Communications (2025). Novel Natural Products with Insecticidal Activity. (https://journals.sagepub.com/topic/collections-npx/npx-001940/npxa). Impact Factor: 1.4 (SCI/PubMed/Medline/Scopus Indexed)
  3. Guest Editor, Horticulturae (2021). Traditional Herbal Medicines in the Management of Health and Agriculture. (https://www.mdpi.com/journal/horticulturae/special_issues/traditional_herbal_medicines). Impact Factor: 2.331 (SCI/PubMed/Medline/Scopus Indexed)
  4. Guest Editor, Recent Patents on Anti-cancer Drug Discovery (2020). Metal nanoparticles as emerging drug candidates in the management of cancers and microbial infectious diseases. (BMS-PRA-2021-HT-4). Impact Factor: 4.610 (SCI/PubMed/Medline/Scopus Indexed)
  5. Guest Editor, Current Drug Targets (2020). Targeting carcinogenesis and cancer progression by Natural products. (BMS-CDT-2020-HT-31). Impact Factor: 3.465 (SCI/PubMed/Medline/Scopus Indexed)

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RESEARCH PROJECTS

  1. Chemical composition, antioxidant, antiinflammatory, and anticancer properties of the essential oils from Ocimum basilicum, O. gratissimum, O. tenuiflorum and O. canum. Kerala State Council for Science, Technology and Environment (2020-2021). Letter No. 00784/SPS65/2021/KSCSTE Dt: 23.12.2021. Role: Principal Investigator
  2. Effect of the Coconut (Cocos nucifera) and Palmyra palm (Borassus flabellifer) haustorium extract on Sodium fluoride induced cytotoxicity and its molecular mechanism of action. Kerala State Council for Science, Technology and Environment (2020-2021). Letter No. 01029/SPS64/2019/KSCSTE Dt: 23.12.2021. Role: Principal Investigator
  3. A study on the phytochemical content and anticancer activity of methanolic extract of Azima tetracantha leaves. Kerala State Council for Science, Technology and Environment (2019-2020). Letter No. 01519/SPS64/2019/KSCSTE Dt: 16.02020. Role: Principal Investigator
  4. Study on the Phenolic constituents and anticancer activity of Amaranthus viridis, A. spinosus and A. dubius. Kerala State Council for Science, Technology and Environemnt (2019-2020). Letter No. 01476/SPS64/2019/KSCSTE Dt: 16.01.2020. Role: Principal Investigator
  5. Study on the Antioxidant, anti-inflammatory and anticancer activities of Thottea siliquosa. RUSA- St. Joseph’s College (Autonomous), Devagiri (2019-2020). Role: Co- Investigator

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Publications

  1. P. M. Padmalayam, A. M. Kuttithodi, A. Tom, J. Tom, S. George, A. Narayanankutty, Phytochemical screening by HRLC-MS/MS (Q-TOF) and antioxidant and anti-inflammatory properties of Thottea sivarajanii leaf extract, Pharmaceuticals, 2025.
  2. Menon, S., Lawrence, L., Sivaram, V.P., Padikkala, J., Mathew, S.E., Narayanankutty, A., (2025). Oroxylum indicum Root Bark Extract Mitigates Hepato-renal Damage induced by Acetaminophen and Cisplatin. Zeitschrift für Naturforschung C. https://doi.org/10.1515/ZNC-2025-0088
  3. Kunnathattil, M., Visakh, N. U., Pathrose, B., Punathil, T., Ravindran, A. E., Narayanankutty, A., Kaimal, S. G. (2025). Evaluation of chemical composition, acaricidal and repellent activities of Artemisia vulgaris L. (Asteraceae) essential oil against gall mite Aceria pongamiae Keifer (Acarina: Eriophyidae). Molecules, 30, 3326. https://doi.org/10.3390/molecules30163326.
  4. Renny, A., Tom, A., Prasad, A., Kuttithodi, A. M., Padmalayam, P. M., George, S., Mathew, S.E., Job, J.T., Narayanankutty, A. (2025). Biogenic Silver Nanoparticles from Thottea siliquosa: Synthesis, Characterization, and Evaluation of Antioxidant, Anti-inflammatory, Anticancer, and Antibacterial Activities. Biocatalysis and Agricultural Biotechnology, 103710. https://doi.org/10.1016/j.bcab.2025.103710
  5. Sivaram, V.P., Mulakkal, J.N., Menon, S., Lawrence, L., Alfarhan, A., Rajagopal R., Narayanankutty, A., Padikkala, J., (2025). Phytochemical Analysis and Protective Effect of Desmodium gyrans DC in Doxorubicin-Induced Cardiomyopathy and Isoproterenol-Induced Myocardial Infarction. Chemistry and Biodiversity. https://doi.org/10.1002/cbdv.202402951
  6. Prasad, A., Sidhic, J., Mohan, C.K., Sarbadhikary, P., George, S., Narayanankutty, A., Tom, R.T., George, B.P. and Abrahamse, H., 2025. Biogenic synthesis of metal oxide nanoparticles for the elicitation of secondary metabolites in the in vitro propagated plantlets of Rubia cordifolia L. Plant Cell, Tissue and Organ Culture (PCTOC), 160(3), 1-17. https://doi.org/10.1007/s11240-025-03009-2
  7. Sidhic, J., Aswathi, M.K., Prasad, A., Tom, A., Mohan, P., Sarbadhikary, P., Narayanankutty, A., George, S., Abrahamse, H. and George, B.P., 2025. Advancements in Metal and Metal Oxide Nanoparticles for Targeted Cancer Therapy and Imaging: Mechanisms, Applications, and Safety Concerns. Journal of Drug Delivery Science and Technology, p.106622. https://doi.org/10.1016/j.jddst.2025.106622
  8. Renny, A., Sidhic, J., Tom, A., Kuttithodi, A.M., Job, J.T., Rajagopal, R., Alfarhan, A., Narayanankutty, A. (2024). Methanol Extract of Thottea siliquosa (Lam.) Ding Hou Leaves Inhibits Carrageenan- and Formalin-Induced Paw Edema in Mice. Molecules 2024, 29, 4800. https://doi.org/10.3390/molecules29204800
  9. Philip, R.S., Narayanankutty, A. and Mathew, M., (2024). The antibacterial efficacy of reduced graphene oxide (rGO) and rGO/ZnO composites produced through thermal pyrolysis method against various bacterial strains. Zeitschrift für Physikalische Chemie. https://doi.org/10.1515/zpch-2024-0777
  10. Maneesha K, Narayanankutty A., Visakh N. U., Pathrose B., Thejass P, Kaimal S. G., (2024). Phytochemical Characterization, Fumigant and Contact Toxicity Activities Of Four Essential Oils Against Eriophyid Gall Mite, Aceria pongamiae Keifer (Acarina: Eriophyidae). Chemistry and Biodiversity, e202401535. https://doi.org/1002/cbdv.202401535
  11. Jahan, N. I., Job, J. T., Alfarhan, A., Rajagopal, R., Kavungal, V., Oprea, E., & Narayanankutty, A. (2024). Elemental composition, antioxidant, anti-inflammatory and anti-genotoxic properties of Nitophyllum punctatum. Journal of King Saud University-Science, 1033 https://doi.org/10.1016/j.jksus.2024.103311
  12. Narayanankutty A., Famurewa A. C., Oprea E.. Natural Bioactive Compounds and Human Health. Molecules. 2024; 29 (14): 3372. https://doi.org/10.3390/molecules 29143372
  13. Prasad, A., Sidhic, J., Sarbadhikary, P., Narayanankutty, A., George, S., George, B. P., & Abrahamse, H. (2024). Role of metal nanoparticles in organogenesis, secondary metabolite production and genetic transformation of plants under in vitro condition: a comprehensive review. Plant Cell, Tissue and Organ Culture (PCTOC), 158(2), 33. https://doi.org/10.1007/s11240-024-02833-2
  14. Nikhitha, D., Narayanankutty, A., Mathews, M., Sathee, D., Alfarhan, A., Rajagopal, R., & Jacob, J. (2024). Bacterioplankton diversity in the estuarine regions of two peninsular rivers: A metagenomic approach. Journal of King Saud University-Science, 103265. https://doi.org/10.1016/j.jksus.2024.103265
  15. Sidhic, J., George, S., & Narayanankutty, A. (2024). Traditional Medicinal Plants in Cancer Therapy and Chemoprevention: A Review of Preclinical and Clinical Studies. Current Nutrition & Food Science, 20(6), 703-7 http://dx.doi.org/10.2174/1573401319666230816141305
  16. Sasidharan, A., Surendran, A., Rajagopal, R., Alfarhan, A., Job, J. T., & Narayanankutty, A. (2024). Allspice (Pimenta dioica) essential oil mediates sphingosine kinase inhibition and subsequent induction of apoptosis in gastric cancer cells. Journal of Essential Oil Bearing Plants, 27(2), 537-546. https://doi.org/10.1080/0972060X.2024.2333778
  17. Ogbu, P. N., Famurewa, A. C., Ugbor, C. K., Ogbu, I. M., Aloke, C., Obasi, N. A., ... & Narayanankutty, A. (2024). HPLC phytochemical profiling, antioxidant activity and in vitro evaluation of inhibitory effects of Terminalia catappa stem bark extract on enzymes linked to diabetes, hypertensive vasoconstriction and erectile dysfunction. Pharmacological Research-Natural Products, 4, 100064. https://doi.org/10.1016/j.prenap.2024.100064
  18. Job J. T., Visakh N. U., Pathrose B., Alfarhan A., Rajagopal R., Thayyullathil J., Thejass P., Ramesh V., Narayanankutty A., Chemical Composition and Biological Activities of the Essential Oil from Citrus reticulata Blanco Peels Collected from Agrowastes. Chemistry and Biodiversity 2023, e202301223. https://doi.org/10.1002/cbdv.202301223
  19. Gupta T, Sahoo NK, Rambabu M, Praveen M, Charde S, Sahu M, Chakrabarti P, Hung BT, Margala M, Unhelkar B, Narayanankutty A. New validated liquid chromatography-tandem mass spectrometry method for the determination of Dacomitinib in human plasma and its application to a pharmacokinetic study. Separation Science Plus. 2023;e2300131. https://doi.org/10.1002/sscp.202300131
  20. Visakh, N.U., Pathrose, B. and Narayanankutty, A., 2023. Characterization of secondary metabolites from the leaves of curry leaf (Murraya koenigii L.) essential oils with insecticidal activities against stored product insects. Biocatalysis and Agricultural Biotechnology, p.102973. https://doi.org/10.1016/j.bcab.2023.102973
  21. Sidhic, J.; George, S.; Alfarhan, A.; Rajagopal, R.; Olatunji, O.J.; Narayanankutty, A. Phytochemical Composition and Antioxidant and Anti-Inflammatory Activities of Humboldtia sanjappae Sasidh. & Sujanapal, an Endemic Medicinal Plant to the Western Ghats. Molecules 2023, 28, 6875. https://doi.org/10.3390/molecules28196875
  22. Narayanankutty A., Metal Nanoparticles as Emerging Drug Candidates in the Management of Cancers and Microbial Infectious Diseases. Recent Patents on Anti-Cancer Drug Discovery 18 (3), 244-245. http://doi.org/10.2174/157489281803230127124009
  23. Tom, A.; Jacob, J.; Mathews, M.; Rajagopal, R.; Alfarhan, A.; Barcelo, D.; Narayanankutty, A. Synthesis of Bis-Chalcones and Evaluation of Its Effect on Peroxide-Induced Cell Death and Lipopolysaccharide-Induced Cytokine Production. Molecules 2023, 28, 6354. https://doi.org/10.3390/molecules28176354
  24. Kuttithodi, A.M.; Narayanankutty, A.; Visakh, N.U.; Job, J.T.; Pathrose, B.; Olatunji, O.J.; Alfarhan, A.; Ramesh, V. Chemical Composition of the Cinnamomum malabatrum Leaf Essential Oil and Analysis of Its Antioxidant, Enzyme Inhibitory and Antibacterial Activities. Antibiotics 2023, 12, 940. https://doi.org/10.3390/antibiotics12050940
  25. Menon, S.; Al-Eisa, R.A.; Hamdi, H.; Lawrence, L.; Syamily, P.S.; Sivaram, V.P.; Padikkala, J.; Mathew, S.E.; Narayanankutty, A. Protective Effect of Annona muricata Linn Fruit Pulp Lyophilized Powder against Paracetamol-Induced Redox Imbalance and Hepatotoxicity in Rats. Processes 2023, 11, 276. https://doi.org/10.3390/pr11010276
  26. Menon, S.; Albaqami, J.J.; Hamdi, H.; Lawrence, L.; Padikkala, J.; Mathew, S.E.; Narayanankutty, A. Oroxylum indicum Vent Root Bark Extract Inhibits the Proliferation of Cancer Cells and Induce Apoptotic Cell Death. Processes 2023, 11, 188. https://doi.org/10.3390/pr11010188
  27. Narayanankutty, A.; Visakh, N.U.; Sasidharan, A.; Pathrose, B.; Olatunji, O.J.; Al-Ansari, A.; Alfarhan, A.; Ramesh, V. Chemical Composition, Antioxidant, Anti-Bacterial, and Anti-Cancer Activities of Essential Oils Extracted from Citrus limetta Risso Peel Waste Remains after Commercial Use. Molecules 2022, 27, 8329. https://doi.org/10.3390/molecules27238329.
  28. Narayanankutty, A., Job, J. T., Moothakoottil Kuttithodi, A., Sasidharan, A., Benil, P. B., Ramesh, V., Mohamed F.E., Rizwana, H, Essam El-Din, M. M. (2023). Proximate composition, antioxidant, anti-inflammatory and anti-diabetic properties of the haustorium from Coconut (Cocos nucifera L.) and Palmyra palm (Borassus flabellifer L.). Journal of King Saud University - Science, 35(1), 102404. https://doi.org/10.1016/j.jksus.2022.102404.
  29. Kuttithodi, A.M.; Nikhitha, D.; Jacob, J.; Narayanankutty, A.; Mathews, M.; Olatunji, O.J.; Rajagopal, R.; Alfarhan, A.; Barcelo, D. Antioxidant, Antimicrobial, Cytotoxicity, and Larvicidal Activities of Selected Synthetic Bis-Chalcones. Molecules 2022, 27, 8209. https://doi.org/10.3390/molecules27238209.
  30. Menon, S.; Albaqami, J.J.; Hamdi, H.; Lawrence, L.; Divya, M.K.; Antony, L.; Padikkala, J.; Mathew, S.E.; Narayanankutty, A. Root Bark Extract of Oroxylum indicum Vent. Inhibits Solid and Ascites Tumors and Prevents the Development of DMBA-Induced Skin Papilloma Formation. Molecules 2022, 27, 8459. https://doi.org/10.3390/molecules27238459.
  31. Albaqami, J.J.; Hamdi, H.; Narayanankutty, A.; Visakh, N.U.; Sasidharan, A.; Kuttithodi, A.M.; Famurewa, A.C.; Pathrose, B. Chemical Composition and Biological Activities of the Leaf Essential Oils of Curcuma longa, Curcuma aromatica and Curcuma angustifolia. Antibiotics 2022, 11, 1547. https://doi.org/10.3390/antibiotics11111547
  32. Albaqami, J.J.; Benny, T.P.; Hamdi, H.; Altemimi, A.B.; Kuttithodi, A.M.; Job, J.T.; Sasidharan, A.; Narayanankutty, A. Phytochemical Composition and In Vitro Antioxidant, Anti-Inflammatory, Anticancer, and Enzyme-Inhibitory Activities of Artemisia nilagirica (C.B. Clarke) Pamp. Molecules 2022, 27, 7119. https://doi.org/10.3390/molecules27207119.
  33. AlFadhly NKZ, Alhelfi N, Altemimi AB, Verma DK, Cacciola F, Narayanankutty A. Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review. Molecules. 2022; 27(17):5584. https://doi.org/10.3390/molecules27175584
  34. Narayanankutty A, Nambiattil S, Mannarakkal S. Phytochemicals and Nanoparticles in the Modulation of PI3K/ Akt/ mTOR Kinases and Its Implications in the Development and Progression of Gastrointestinal Cancers: A Review of Preclinical and Clinical Evidence. Recent Patents on Anti-Cancer Drug Discovery. 2022. http://dx.doi.org/10.2174/1574892817666220606104712.
  35. Visakh NU, Pathrose B, Narayanankutty A, Alfarhan A, Ramesh V. Utilization of Pomelo (Citrus maxima) Peel Waste into Bioactive Essential Oils: Chemical Composition and Insecticidal Properties. Insects. 2022; 13(5):480. https://doi.org/10.3390/insects13050480
  36. Sneha K, Narayanankutty A, Job JT, Olatunji OJ, Alfarhan A, Famurewa AC, Ramesh V. Antimicrobial and Larvicidal Activities of Different Ocimum Essential Oils Extracted by Ultrasound-Assisted Hydrodistillation. Molecules. 2022; 27(5):1456. https://doi.org/10.3390/molecules27051456
  37. Ademola C. Famurewa, Ekenechukwu Maduagwuna, Chinyere Aloke, Sharon O. Azubuike-Osu, Narayanankutty A. Virgin coconut oil ameliorates arsenic hepatorenal toxicity and no-mediated inflammation via suppression of oxidative stress in rats. Thai Journal of Pharmaceutical Sciences. 2022; 46(2):167-172.
  38. Kim YO, Narayanankutty A, Kuttithodi AM, Kim HJ, Na SW, Kunnath K, Rajagopal R, Alfarhan A. Azima tetracantha Leaf Methanol Extract Inhibits Gastric Cancer Cell Proliferation through Induction of Redox Imbalance and Cytochrome C Release. Applied Sciences. 2022; 12:1: 120. https://doi.org/10.3390/app12010120
  39. Alby T, Job JT, Narayanankutty A, Rajagopal R, Alfarhan A, Ramesh V (2021). Thottea siliquosa (Lam). Ding Hou leaf methanolic extract inhibits lipopolysaccharide induced TLR4 activation and cytokine production as well as ethyl methyl sulfonate induced genotoxicity. Physiological and Molecular Plant Pathology:101746.  https://doi.org/10.1016/j.pmpp.2021.101746
  40. Narayanankutty, A., Sasidharan A., Job J.T., Ramesh V., Rajagopal R., Alfarhan A., Kim Y., Kim H.J., (2021). Mango ginger (Curcuma amada Roxb.) rhizome essential oils as source of environmental friendly biocides: Comparison of the chemical composition, antibacterial, insecticidal and larvicidal properties of essential oils extracted by different methods. Environmental Research, 202: 111718. https://doi.org/10.1016/j.envres.2021.111718
  41. Kim H-J, Narayanankutty A, Sasidharan A, Tom Job J, Ock Kim Y, Won Na S, Rajagopal R, Alfarhan A, Al-Munqedhi B (2021) Methanolic extract of coconut (Cocos nucifera L.) haustorium mitigates pro-oxidant-mediated apoptotic cell death via Nrf-2 pathway and lipopolysaccharide-induced cytokine release in cells. Journal of King Saud University - Science:101715. (Published ahead of Print). https://doi.org/10.1016/j.jksus.2021.101715
  42. Job J.T., Ramesh V., Rajagopal R., Ramesh V., Alfarhan A., Narayanankutty, A., (2021). Toxic effects of fluoride in intestinal epithelial cells and the mitigating effect of methanol extract of Coconut haustorium by enhancing de novo glutathione biosynthesis. Environmental Research, 200: 111717. https://doi.org/10.1016/j.envres.2021.111717
  43. Narayanankutty A, Kunnath K, Famurewa AC, Ramesh V, Rajagopal R, Alfarhan A (2021) Variations in the composition, cytoprotective and anti-inflammatory effects of natural polyphenols of edible oils extracted from fresh and dried coconut testa Physiological and Molecular Plant Pathology:101742. https://doi.org/10.1016/j.pmpp.2021.101742
  44. Narayanankutty. A, Aswathi MK, Alfarhan A., Rajagopal R., Barcelo D. Chemical composition of Allspice (Pimenta dioica) essential oil and its insecticidal and mosquito larvicidal activities. Molecules. 26, 6698. https://doi.org/10.3390/molecules26216698
  45. Anusmitha KM, Aruna M, Job JT, Narayanankutty A, Pb B, Rajagopal R, Alfarhan A, Barcelo D (2021) Phytochemical analysis, antioxidant, anti-inflammatory, anti-genotoxic and anticancer activities of different ocimum plant extracts prepared by ultrasound-assisted method Physiological and Molecular Plant Pathology:101746.  https://doi.org/10.1016/j.pmpp.2021.101746
  46. Narayanankutty. A, Kunnath K, Alfarhan A., Rajagopal R., Ramesh V (2021). Chemical composition of Cinnamomum verum leaf and flower essential oils and analysis of their antibacterial, insecticidal, and larvicidal properties. Molecules. https://doi.org/10.3390/molecules26206303
  47. Suseela I.M., Narayanankutty A., Smitha K R, Jeksy J M, Vipin P S, Shaji E M, Ramya M K, Padikkala J, and A C Raghavamenon (2021). Desmodium gyrans DC modulates lipid trafficking in cultured macrophages and improves functional HDL in male Wistar rats. Indian Journal of Pharmacology (Accepted). https://pubmed.ncbi.nlm.nih.gov/34414906/
  48. Illam S.P., Kandiyil S.P., Narayanankutty, A., Veetil S.V., Babu T.D., Uppu R.M., Raghavamenon A.C. (2021). Virgin coconut oil complements with its polyphenol components mitigate sodium fluoride toxicity in vitro and in vivo. Drug and Chemical Toxicology. https://doi.org/10.1080/01480545.2021.1926476
  49. Narayanankutty, A., Krishnaprasad K., Jose B., Ramesh V., Rajagopal R., Alfarhan A. (2021). Analysis of the chemical composition of root essential oil from Indian Sarsaparilla (Hemidesmus indicus) and application as ecofriendly insecticide and pharmacological agent. Saudi Journal of Biological Sciences, (Accepted). https://doi.org/10.1016/j.sjbs.2021.08.028
  50. Malayil, D., Jose B., Narayanankutty, A., Ramesh V., Rajagopal R., Alfarhan A. (2021). Phytochemical profiling of Azima tetracantha Lam. leaf methanol extract and elucidation of its potential as a chain-breaking antioxidant, anti-inflammatory and anti-proliferative agent. Saudi Journal of Biological Sciences, (Accepted). https://doi.org/10.1016/j.sjbs.2021.07.090
  51. Narayanankutty, A. (2021). Pharmacological potentials and Nutritional values of Tropical and Sub-tropical Fruits of India: Emphasis on their anticancer bioactive components. Recent Patents on Anti-Cancer Drug Discovery. (Accepted).
  52. Narayanankutty A., (2021). Inhibitory Potential of Dietary Nutraceuticals on Cellular PI3K/Akt Signaling: Implications in Cancer Prevention and Therapy. Current Topics in Medicinal Chemistry (Epub). https://doi.org/10.2174/1568026621666210716152224
  53. Job J.T., Rajagopal R., Alfarhan A., Kim Y., Kim H.J., Narayanankutty, A., (2021). Protective effect of Borassus flabellifer haustorium extract against alkoxyl radical-induced cytotoxicity by improving glutathione metabolism by modulating Nrf2/Haeme oxygenase-1 expression. Journal of the American College of Nutrition, https://doi.org/10.1080/07315724.2021.1942313
  54. Job, J.T., Rajagopal R., Alfarhan A., Narayanankutty, A., (2021). Borassus flabellifer Linn haustorium methanol extract mitigates fluoride-induced apoptosis by enhancing Nrf2/Haeme oxygenase 1 –dependent glutathione metabolism in intestinal epithelial cells. Drug and Chemical Toxicology, https://doi.org/10.1080/01480545.2021.1926476
  55. Illam S.P., Narayanankutty A, Kandiyil S.P., and Raghavamenon A C (2021). Variations in natural polyphenols determine the anti-inflammatory potential of virgin coconut oils. Journal of Food Science, https://doi.org/10.1111/1750-3841.15705
  56. Koottasseri A., Babu A., Augustine A., Job, JT., Narayanankutty A. (2021). Antioxidant, Anti-Inflammatory and Anticancer Activities of Methanolic Extract of Thottea siliquosa: An In Vitro and In Silico Study. Recent Patents on Anti-Cancer Drug Discovery 15. https://doi.org/10.2174/1574892816666210401143750
  57. Narayanankutty A. (2021). Natural Products as PI3K/ Akt Inhibitors: Implications in Preventing Hepatocellular Carcinoma. Current Molecular Pharmacology 15. https://doi.org/10.2174/1874467214666210120152657
  58. Malayil, D., House, N.C., Puthenparambil, D., Job, J.T., Narayanankutty, A., (2020). Borassus flabellifer haustorium extract prevents pro-oxidant mediated cell death and LPS-induced inflammation. Drug and Chemical Toxicology, 1-7. https://doi.org/10.1080/01480545.2020.1858854
  59. Sathyan A.M., Asifa K.P., Narayanankutty A. (2020). Natural bioactive compounds in preventing breast cancer: Role of phytoestrogens. Current Drug Targets (E-Pub). https://doi.org/10.2174/1389450121999201109215341
  60. Narayanankutty A., Kuzhivelil B.T., Raghavamenon AC (2020). A high-fructose diet formulated with thermally oxidized monounsaturated fat aggravates metabolic dysregulation in colon epithelial tissues of rats. Journal of the American College of Nutrition (Ahead of Print) https://doi.org/10.1080/07315724.2020.1846145
  61. Narayanankutty A., Illam SP., Rao V., Shehabudheen S., Raghavamenon AC (2020). Hot-processed virgin coconut oil abrogates cisplatin-induced nephrotoxicity by restoring redox balance in rats compared to fermentation-processed virgin coconut oil. Drug and Chemical Toxicology (Ahead of Print) https://doi.org/10.1080/01480545.2020.1831525
  62. Narayanankutty A. (2020). Phytochemicals as PI3K/ Akt/ mTOR Inhibitors and Their Role in Breast Cancer Treatment. Recent Patents on Anti-Cancer Drug Discovery 15. https://doi.org/10.2174/1574892815666200910164641
  63. Cheerakuzhy House N.C., Puthenparampil D., Malayil D., Narayanankutty A., (2020). Variation in the polyphenol composition, antioxidant and anticancer activity among different Amaranthus species. South African Journal of Botany 135: 408-412. https://doi.org/10.1016/j.sajb.2020.09.026
  64. Narayanankutty A., Sasidharan A., and Job JT (2020). Targeting Toll like Receptors in Cancer: Role of TLR natural and synthetic modulators. Current Pharmaceutical Design (Ahead of Print). https://doi.org/10.2174/1381612826666200720235058
  65. Narayanankutty A., Nair A., Illam SP., Upaganlawar A., Raghavamenon AC (2020). Curcumin enriched VCO protects against 7, 12-Dimethyl Benz [a] anthracene-induced skin papilloma in mice. Nutrition and Cancer: An International Journal (Ahead of Print) https://doi.org/10.1080/01635581.2020.1778745
  66. Illam S.P., Hussain A, Elizabeth A, Narayanankutty A. Raghavamenon AC (2019). Natural combination of phenolic glycosides from fruits resists pro-oxidant insults to colon cells and enhances intrinsic antioxidant status in mice. Toxicological Reports 18;6:703-711. https://doi.org/10.1016/j.toxrep.2019.07.005
  67. Narayanankutty A. (2019). PI3K/Akt/mTOR pathway as a therapeutic target for colorectal cancer: A review of preclinical and clinical evidence. Current Drug Targets 20 (12), 1217-1226. https://doi.org/10.2174/1389450120666181211111815
  68. Sheela, D.L., Narayanankutty A, Nazeem P.A., Raghavamenon A C.,  Shylaja M. R. (2019). Lauric acid induces cell death in colon cancer cells mediated by the Epidermal Growth Factor Receptor downregulation: An In silico and In vitro study. Human and Experimental Toxicology 38(7): 753-761. https://doi.org/10.1177/096032711983918
  69. Narayanankutty A. (2019). Toll like receptors as a novel therapeutic target for natural products against degenerative disorders. Current Drug Targets 20 (10), 1068-1080. https://doi.org/10.2174/1389450120666190222181506
  70. Narayanankutty A, Job T.J., Narayanankutty V (2019). Glutathione, an antioxidant tripeptide: Dual roles in Carcinogenesis and Chemoprevention. Current Protein & Peptide Science 20(9): 907-917. https://doi.org/10.2174/1389203720666190206130003
  71. Narayanankutty V, Narayanankutty A, Nair A (2018). Heat shock proteins (HSPs): A novel target for cancer metastasis prevention. Current Drug Targets 20(7):727-737. https://doi.org/10.2174/1389450120666181211111815
  72. Narayanankutty A, Anil A, Illam S.P., Kandiyil S.P., and Raghavamenon A C (2018). Non-polar lipid carbonyls of thermally oxidized coconut oil induce hepatotoxicity mediated by redox imbalance. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 138: 45-51. https://doi.org/10.1016/j.plefa.2018.10.004
  73. Narayanankutty A., S.P. Illam, & Raghavamenon A.C. (2018) Health impacts of different edible oils prepared from coconut (Cocos nucifera): A comprehensive review. Trends in Food Science & Technology. 80: 1-7. https://doi.org/10.1016/j.tifs.2018.07.025
  74. Narayanankutty A., Gopinath MK, Vakayil M, Ramavarma SK, Babu TD and Raghavamenon AC (2018), Non-enzymatic conversion of primary oxidation products of Docosahexaenoic acid into less toxic acid molecules. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 203: 222-228. https://doi.org/10.1016/j.saa.2018.05.082
  75. Narayanankutty A., Palliyil D.M., Kuruvilla K. and A. C Raghavamenon (2017) Virgin coconut oil reverses hepatic steatosis by restoring redox homeostasis and lipid metabolism in male Wistar rats. Journal of the Science of Food and Agriculture, 98(5):1757-1764. https://doi.org/10.1002/jsfa.8650
  76. Roy N., Nazeem P. A., Babu T. D., Abida P. S., Narayanankutty, A., Valsalan R., Valsala P. A., and Raghavamenon A. C. (2017). EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide. Interdisciplinary Sciences: Computational Life Sciences https://doi.org/10.1007/s12539-017-0227-6
  77. Lekshmi Sheela, D., Abdulla Nazeem P, Narayanankutty A, Shylaja Muthangaparambil R, Davis S P, James P, Valsalan R, Devassy Babu T and Raghavamenon A C (2017). Coconut phytocompounds inhibits polyol pathway enzymes: Implication in prevention of microvascular diabetic complications. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 127: 20-24 https://doi.org/10.1016/j.plefa.2017.1010.1004
  78. Illam S.P., Narayanankutty A., E.M. Shaji, V. Remya, M. Rosemol & A.C. Raghavamenon (2017) Epithelial Mesenchymal Transition in Cancer Progression: Preventive Phytochemicals. Recent Patents on Anti-Cancer Drug Discovery 12 (3): 234-246. https://doi.org/10.2174/1574892812666170424150407
  79. Illam S.P., Narayanankutty A., & A.C. Raghavamenon (2017) Polyphenols of Virgin coconut oil prevent pro-oxidant mediated cell death. Toxicology Mechanism and Methods 27(6):442-450. https://doi.org/10.1080/15376516.2017.1320458
  80. Mukundan S. and Narayanankutty A. (2017) Traditional Fruits of Kerala: Bioactive Compounds and their Curative Potential in Chronic Diseases. Current Nutrition & Food Science. 13(4): 279- 289. https://doi.org/10.2174/1573401313666170206164643
  81. Narayanankutty A., Anagha K., Shaji E.M., Illam S.P., Suseela I.M. and Achuthan C Raghavamenon (2017) Vitamin E supplementation modulates the effect of Omega 3 fatty acids treatment in aged rats, Toxicology Mechanisms and Methods, 27(3): 207-214 https://doi.org/101080/15376516.2016.1273431
  82. Narayanankutty A., Jeksy J. M., Suseela I.M., Smitha K. R., Shaji E. M., Illam S.P., Babu T.D., Balu T. K. and Raghavamenon A.C. (2017) Deep fried edible oils disturbs hepatic redox equilibrium and heightens lipotoxicity and hepatosteatosis in rats. Human and Experimental Toxicology 36 (9): 919-930. https://doi.org/10.1177/0960327116674530
  83. Lekshmi D.S., Nazeem P.A., Narayanankutty A., Jeksy J.M., and Raghavamenon A.C. (2016) In Silico and Wet Lab Studies Reveal the Cholesterol Lowering Efficacy of Lauric Acid a Medium Chain Fat of Coconut Oil. Plant Foods for Human Nutrition, 71 (4): 410-415 https://doi.org/10.1007/s11130-016-0577-y
  84. Narayanankutty A., Muneera V, Jeksy J.M., Smitha K.R., Indu M. Suseela, Babu T.D. and Raghavamenon A.C. (2016) Omega 3 fatty acids: Do they raise health concerns? JSM Biochemistry and Molecular biology, 3(1): 1016.
  85. Roy N., Narayanankutty A., Nazeem P. A., Valsalan R, Babu T. D. and Mathew D. (2016) Plant phenolics ferulic acid and p-coumaric acid inhibits colorectal cancer cell proliferation by through EGFR down regulation. Asian Pacific Journal of Cancer Prevention 17(8): 4017-4021. https://pubmed.ncbi.nlm.nih.gov/27644655/
  86. Roy N., Davis S., Narayanankutty A., Nazeem P.A., Babu T. D., Abida P.S., Valsala P.A., Raghavamenon A. C. (2016). Garlic phytocompounds possess anticancer activity by specifically targeting breast cancer biomarkers: An In silico study. Asian Pacific Journal of Cancer Prevention 17(6): 2883-2888. https://pubmed.ncbi.nlm.nih.gov/27356707/
  87. Narayanankutty A., Reshma K. M., Shabna K. A., Smitha K. R., Indu M. S., Jeksy J. M., Balu T. K. and Achuthan C. Raghavamenon (2016). Virgin coconut oil maintains redox status and improves glycemic conditions in high fructose fed rats. Journal of food science and technology, 53 (1): 895-901. https://doi.org/10.1007/s13197-015-2040-8
  88. Jeksy J.M., Indu M. S., Smitha K. R., Narayanankutty A. and Achuthan C. Raghavamenon (2015). Component Authentication and Standardisation of an Anti-atherosclerotic Herbal Formulation-GSTC3. Pharmacognosy Journal, 7 (6): 339-343. http://dx.doi.org/10.5530/pj.2015.6.4

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Invited Talk/ Session Chaired:

  1. Arunaksharan Narayanankutty, Soorya PI, Balu T K and Achuthan C. Raghavamenon. “Thermally oxidized edible oils enhance hepatosteatosis in male Wistar rats by inducing redox imbalance and pro-inflammatory insults”. 36th Annual Convention of Indian Association of Cancer Research, Thrissur, February 09-11, 2017.
  2. Arunaksharan Narayanankutty, Soorya PI, Balu T K and Achuthan C. Raghavamenon. “Thermally oxidized edible oil rich in polyunsaturated fats disturbs hepatic redox equilibrium and heightens hepatic steatosis in rats”. 12th International Conference of Asian Clinical Oncologist Society and 35th Annual Convention of Indian Association of Cancer Research, New Delhi, April 08-10, 2016.
  3. Arunaksharan Narayanankutty, Jeksy J M, Balu T K and Achuthan C. Raghavamenon. “Prolonged consumption of thermally oxidized dietary fats induces hyperglycemia and alters oxidative homeostasis in the Colonic epithelium”. 6th International Translational Cancer Research Conference- Prevention and Treatment of Cancer: Hypes and Hopes, Ahmedabad, February 04-07, 2016.
  4. Devika Mukundan, Ramya M K, Arunaksharan Narayanankutty, Indu M S, Shaji E M, Kezia Kuruvilla, Achuthan C. Raghavamenon. Virgin coconut oil alleviates non-alcoholic hepatic steatosis in Wistar Rats. 28th Kerala Science Congress, January 27-30, 2016.
  5. Arunaksharan Narayanankutty, Midhun K G, Shelsa K. James and Achuthan C. Raghavamenon. “Molecules generated from oxidized DHA and EPA induces carbonyl stress and cytotoxicity in cellular milieu.” Recent developments in cancer biology, Pazhassiraja College, Sultan Battery, 22-24 July, 2015.
  6. Arunaksharan Narayanankutty, Smitha K R, Indu M S, Jeksy M J and Achuthan C. Raghavamenon. “Thermally oxidized coconut oil fed rats are more susceptible to changes associated with hepatic steatosis than fresh oil.” National conference on advances in laboratory practices, M.E.S. College, Perinthalmanna, 14-15 June, 2015.
  7. Arunaksharan Narayanankutty, K M Reshma and Achuthan C. Raghavamenon. “Virgin coconut oil as fatty acid source in high fructose diet reduces hyperglycemia and oxidative stress in Wistar rats”. 27th Kerala Science Congress, Alappuzha, 28-30 January, 2015.
  8. Arunaksharan Narayanankutty, Shweta Mukundan, George Mathew and Jomy John. A Preliminary Ecological Study of Azhingillam Wetlands with Special Emphasis on Water Fowl Fauna. Proceedings of the National Conference on Modern Trends in Zoological Research. St. Aloysius College, Elthuruth, 25-26 March, 2014.

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Presentations:

  1. Arunaksharan Narayanankutty, Soorya PI, Balu T K and Achuthan C. Raghavamenon. “Thermally oxidized edible oils enhance hepatosteatosis in male Wistar rats by inducing redox imbalance and pro-inflammatory insults”. 36th Annual Convention of Indian Association of Cancer Research, Thrissur, February 09-11, 2017.
  2. Arunaksharan Narayanankutty, Soorya PI, Balu T K and Achuthan C. Raghavamenon. “Thermally oxidized edible oil rich in polyunsaturated fats disturbs hepatic redox equilibrium and heightens hepatic steatosis in rats”. 12th International Conference of Asian Clinical Oncologist Society and 35th Annual Convention of Indian Association of Cancer Research, New Delhi, April 08-10, 2016.
  3. Arunaksharan Narayanankutty, Jeksy J M, Balu T K and Achuthan C. Raghavamenon. “Prolonged consumption of thermally oxidized dietary fats induces hyperglycemia and alters oxidative homeostasis in the Colonic epithelium”. 6th International Translational Cancer Research Conference- Prevention and Treatment of Cancer: Hypes and Hopes, Ahmedabad, February 04-07, 2016.
  4. Devika Mukundan, Ramya M K, Arunaksharan Narayanankutty, Indu M S, Shaji E M, Kezia Kuruvilla, Achuthan C. Raghavamenon. Virgin coconut oil alleviates non-alcoholic hepatic steatosis in Wistar Rats. 28th Kerala Science Congress, January 27-30, 2016.
  5. Arunaksharan Narayanankutty, Midhun K G, Shelsa K. James and Achuthan C. Raghavamenon. “Molecules generated from oxidized DHA and EPA induces carbonyl stress and cytotoxicity in cellular milieu.” Recent developments in cancer biology, Pazhassiraja College, Sultan Battery, 22-24 July, 2015.
  6. Arunaksharan Narayanankutty, Smitha K R, Indu M S, Jeksy M J and Achuthan C. Raghavamenon. “Thermally oxidized coconut oil fed rats are more susceptible to changes associated with hepatic steatosis than fresh oil.” National conference on advances in laboratory practices, M.E.S. College, Perinthalmanna, 14-15 June, 2015.
  7. Arunaksharan Narayanankutty, K M Reshma and Achuthan C. Raghavamenon. “Virgin coconut oil as fatty acid source in high fructose diet reduces hyperglycemia and oxidative stress in Wistar rats”. 27th Kerala Science Congress, Alappuzha, 28-30 January, 2015.
  8. Arunaksharan Narayanankutty, Shweta Mukundan, George Mathew and Jomy John. A Preliminary Ecological Study of Azhingillam Wetlands with Special Emphasis on Water Fowl Fauna. Proceedings of the National Conference on Modern Trends in Zoological Research. St. Aloysius College, Elthuruth, 25-26 March, 2014.

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